Orion - a new standard in OCT segmentation software.


Device-independent 8 retinal layer segmentation software.

Voxeleron is pleased to offer OrionTM, advanced optical coherence tomography (OCT) analysis software for research use only*.  OrionTM is fully-automated software, rapidly and accurately segmenting up to eight retinal layers in OCT images.

See Orion in action here.

The limited functionality of existing OCT analysis tools has meant that only two or three retinal layers are analyzed, despite the overwhelming evidence for the clinical importance of the inner retinal layers in disease detection and prognosis.  OrionTM  addresses exactly this technology gap, providing researchers much needed biomarkers for the early detection and prognosis of ophthalmic and neurological diseases.

Previously voted as one of the year’s best innovations in the Ophthalmologist, OrionTM is a fully automated research tool designed to rapidly and accurately segment eight retinal layers in OCT images.  The software is platform independent, processing data from all the main OCT scanners, and provides a comprehensive tool for quantifying retinal thickness in the human retina.  OrionTM has been validated in two separate studies, and thoroughly beta tested at a number of clinical sites around the world.

As well as unrivaled image format support, OrionTM has a comprehensive set of features, including 3d visualization, layer editing wizards, angiography support, batch processing, and region of interest (ROI) analysis.

*Please note: OrionTM has not been approved for clinical use.  It is a research tool, and may not be used to support the treatment or diagnosis of human patients.

Orion's automated analyses support structural and functional biomarkers. Here an avascular region in the choriocapillaris corresponds to a PED.

A window to the brain

Five million Americans suffer from Alzheimer’s disease, one million from Parkinson’s, 30,000 from amyotrophic lateral sclerosis (ALS), and it is estimated that 400,000 (1999) Americans are taken early from the workforce due to multiple sclerosis (MS), a disease whose onset afflicts younger populations.  As an extension of the central nervous system, the health of the retina is closely tied to the health of the brain.  Early work studying deeper layers of the retina has shown potential for early detection and accurate diagnosis or some of the most debilitating neurological diseases.  A number of recent studies have tied retinal layer thicknesses to an increasing number of pathologies, including:

Summary findings of disease and affected retinal layers.

Early detection of these diseases can offer a number of potential interventional options and clinical endpoints.  OrionTM is unique in offering the ability to isolate and quantify these layers, empowering fundamental clinical research.  For further details please email us at orion@voxeleron.com, or to see OrionTM in action, visit our video tutorials webpage.

Screenshot of 8 retinal layer segmentation with Orion. Despite the inflammation the ganglion cell complex is accurately segmented.
Screenshot of the new peripapillary segmentation page, featuring the at a glance thickness map.
Using the RPE-baseline, it is possible to quantify RPE elevation volume as seen in the data.
With Orion's intelligent editing wizard, surfaces may be edited or indeed added in seconds.

Orion’s Roadmap

Future releases are coming as we have an extensive product roadmap!  Soon we will introduce a deep-learning based approach to B-scan abnormality detection and more comprehensive support for angiography quantification will be rolled out in summer.  By fall a comprehensive suite of change analysis tools, which will include fully automated 3d alignment, a first in the world of OCT, will be released.  So do watch this space for further updates (or even easier, just sign up below)!

Orion Information List Signup


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